DYMO 550 series label printers will only work with DYMO manufactured labels. They do not work with generic or compatible labels like the 450 series did.
In addition, DYMO only manufactures a small variety of LabelWriter options. If you use a specialty size, shape, color, or material, these 450 labels will not work with the DYMO 550 Series. There is an alternative, however, that is still available to purchase that does work with all Dymo 450 labels.
DYMO LabelWriter 4XL Still Works With Dymo 450 Labels
The Dymo LabelWriter 4XL is currently still in production and able to be purchased. This 450 series DYMO printer will accept generic, compatible, and custom Dymo labels.